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This webinar offers a deep dive into the complex and evolving landscape of hyperinflammatory syndromes, with a focus on understanding their underlying mechanisms, clinical presentations, and diagnostic challenges. Hyperinflammatory syndromes represent a spectrum of severe immune dysregulation, often characterized by excessive cytokine release and multi-organ involvement. These conditions can be life-threatening and are increasingly recognized across various clinical contexts.

Audi Setiadi, MD, FRCPC, hematopathologist and investigator at BC Children’s Hospital, will begin by defining hyperinflammatory syndromes and exploring their common features, including the role of cytokine dysregulation and immune system overactivation. A central focus will be on hemophagocytic lymphohistiocytosis (HLH) – a rare but critical condition – and cytokine release syndrome (CRS), which frequently occurs in the setting of CAR T-cell therapy and other immunotherapies.

Key topics covered include:

  • Overview of hyperinflammatory syndromes and their clinical relevance
  • Introduction to HLH: diagnostic criteria, triggers, and pathogenesis
  • Understanding CRS and its overlap with HLH
  • Basics of CAR T-cell therapy and its associated immune-related adverse events
  • The pathophysiology of cytokine storms and their systemic impact
  • Interpretation of cytokine profiles and inflammatory markers
  • Diagnostic challenges and differential diagnosis in hyperinflammatory states
  • Case-based discussions and emerging approaches to evaluation and management

This session is designed for clinicians, laboratory professionals, and researchers interested in improving their understanding of hyperinflammation in both traditional and novel therapeutic contexts.

Attendees will gain insights into the interplay between immune activation and clinical manifestations, and how evolving diagnostic tools can aid in timely recognition and intervention.

Learning objectives:

  • Describe the immunopathogenesis and clinical features of hyperinflammatory syndromes, including HLH and cytokine release syndrome, and differentiate them from other inflammatory conditions.
  • Identify key laboratory and clinical markers, including cytokine profiles, that support the recognition and evaluation of hyperinflammatory states.
  • Explain the mechanisms and potential complications of CAR T-cell therapy, with a focus on immune-related adverse events such as CRS and HLH-like presentations.

Accreditation statement

SelectScience® is approved as a provider of continuing education programs in the clinical laboratory sciences by the ASCLS P.A.C.E.® Program. Attendees of these webinars may be entitled to 1.0 ACCENT Continuing Education Credits from the ADLM. This activity was planned in accordance with ACCENT® Standards and Policies. Verification of Participation certificates are provided to registered participants based on completion of the activity, in its entirety, and the activity evaluation. For questions regarding continuing education, please email education@myadlm.org

Presenters

Dr. Audi Setiadi
Dr. Audi Setiadi

MD, FRCPC

Medical Director; Clinical Associate Professor, British Columbia Children’s Hospital; University of British Columbia

Audi Setiadi, MD, is a hematopathologist and investigator at BC Children’s Hospital and Clinical Associate Professor at the University of British Columbia. Her work focuses on inborn errors of immunity and hemophagocytic lymphohistiocytosis (HLH), with expertise in diagnostic immunology, flow cytometry, and cellular therapy for immune dysregulation and post-transplant complications.
Charlie Carter
Charlie Carter

Associate Editor

SelectScience

Charlie studied neuroscience at the University of Bristol, UK, before completing a Masters in Science Communication. As a member of the Editorial team, Charlie plays an integral role in shaping the content on SelectScience.

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