Wednesday, March 25 at 15:00 GMT / 16:00 CET / 11:00 EDT / 08:00 PDT

Accurate interpretation of pediatric test results continues to represent a recognized gap in laboratory medicine. High resolution, age-dependent reference intervals are essential for differentiating normal developmental variation from true pathology, yet conventional population-based approaches remain constrained by feasibility and ethical limitations. Novel indirect methods and large-scale, real-world datasets now offer viable pathways to improve accuracy, reduce bias, and increase applicability across diverse pediatric populations.

This SelectScience® webinar, presented by pediatric hemato-oncologist PD Dr. med. Jakob Zierk, equips participants with the competencies required to evaluate these methods and integrate data-driven pediatric intervals into clinical practice.

The webinar will cover the following topic areas:

  • Challenges associated with pediatric reference interval development.
  • Why conventional approaches to reference interval establishment are insufficient for pediatrics.
  • Overview of indirect data-driven methodologies.
  • Comparison of available indirect methods and published evidence.
  • Use of large federated datasets and decentralized analysis.
  • Application examples and first results.
  • Outlook on pediatric reference intervals for coagulation assays and future analytes.

Key learning objectives:

  • Describe the key physiological developmental processes that produce age- and sex-specific variation in pediatric biochemical analytes, and identify at least two such developmental factors.
  • Differentiate between conventional and indirect methodologies for establishing pediatric reference intervals and explain how indirect data driven approaches more accurately support clinical interpretation of pediatric laboratory results.
  • Evaluate the ethical and operational constraints associated with collecting pediatric reference samples and propose at least one evidence-based, data-driven strategy to mitigate these limitations within clinical laboratory practice.

Who should attend?

Lab directors, pediatricians, hemostaseologists, and hematologists.

Accreditation statement

SelectScience® is approved as a provider of continuing education programs in the clinical laboratory sciences by the ASCLS P.A.C.E.® Program.

Webinar details

  • Cost: Free to attend
  • Location: Online
  • Duration: 60 minutes
  • Instruction level: Intermediate

Registration is required to secure your place. If you register but can’t attend live, you will receive a link to the on‑demand recording once it becomes available.

Presenters

PD Dr. med. Jakob Zierk
PD Dr. med. Jakob Zierk

Senior Physician, Department of Paediatrics and Adolescent Medicine, University Clinic Erlangen

Dr. Jakob Zierk is a pediatric hemato-oncologist with a research interest in pediatric reference intervals. His focus is on indirect methods for reference intervals (e.g. refineR) and their application to large pediatric datasets. He serves as the principal investigator of the PEDREF study, in which laboratory data from more than 20 German centers are analyzed to establish next-generation pediatric reference intervals.

Sarah Thomas
Sarah Thomas

Associate Editor

SelectScience

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